Skip to main content

An Insight to Application of Computational Statistics and computational Biology in Bioinformatics


An Insight to Application of Computational Statistics and Computational Biology in Bioinformatics
  • August 2012
  • In book: Applied Computational Biology and Statistics in Biotechnology and Bioinformatics
  • Edition: 1
  • Chapter: ch-36
  • Publisher: NIPA,New Delhi
  • Editors: akroy
  • Ajit kumar RoyAjit kumar Roy
    • Computation has become an essential tool in life science research. This is exemplified in genomics, where first microarrays and now massively parallel DNA sequencing have enabled a variety of genome-wide functional assays that require increasingly complex analysis tools. The problem of accessibility of computational tools has long been recognized. Without programming or informatics expertise, scientists needing to use computational approaches are impeded by problems ranging from tool installation; to determining which parameter values to use; to efficiently combining multiple tools together in an analysis chain. The severity of these problems is evidenced by the numerous solutions to address them. Knowledge on software and web-based interfaces for tools all improve the accessibility of computation. These approaches each have advantages, but do not offer a general solution that enables a computational tool to be easily included in an analysis chain and run by scientists without programming experience. However, making tools accessible does not necessarily address the crucial problem of reproducibility. For computational experiments, researchers have argued that computational results, such as analyses and methods, are of equal or even greater importance than text and figures as experimental outputs. In this chapter, it is attempted to highlight basic concept of new biology, tools, techniques of computational biology and computational statistics applied in biotechnology and bioinformatics. Further some of the common useful statistical aspects of microarray data analysis, including detection of differential expression methods are highlighted.
      … 








      +2


Comments

Post a Comment

Popular posts from this blog

Bioinformatics Resources on Web

Bioinformatics Resource on the Web(Freely Available) Nucleotide Sequence Databases (the principal ones) ·          NCBI  - National Center for Biotechnology Information ·          EBI  - European Bioinformatics Institute ·          DDBJ  - DNA Data Bank of Japan Protein Sequence Databases ·          SWISS-PROT & TrEMBL  - Protein sequence database and computer annotated supplement ·          UniProt  - UniProt (Universal Protein Resource) is the world's most comprehensive catalog of information on proteins. It is a central repository of protein sequence and function created by joining the information contained in Swiss-Prot, TrEMBL, and PIR. ·          PIR  - Protein Information Resource ·  ...
Post a Comment
Read more

Modelling Forecasting Artificial Neural Network and Expert System in Fisheries and Aquaculture

The book entitled 'Modelling Forecasting Artificial Neural Network and Expert System in Fisheries and Aquaculture is the first of its kind available in the market. The book contains altogether sixteen chapter covering both capture and culture fisheries aspects contributed by various subject matter specialists engaged in research and development activities at various national institutes of repute. Each of the chapters has been specially written by an expert in the field bringing together in a single volume a range of approaches and reviews covering conceptual and mathematical model empirical and theoretical model deterministic and stochastic model biological model pond ecosystem model and explanatory models. Both linear as well as nonlinear models applied to fisheries and aquaculture research has been dealt with illustrated examples on current real fisheries data. Adequate attention has been given to select chapters that contain both theoretical as well as applied areas of researc...
Post a Comment
Read more

Post Demonetization Budget-2017- Expectations, Apprehensions and Reality: India's Budget-2017

Post Demonetization Budget-2017- Expectations, Apprehensions and Reality: India's Budget-2017 (Demonetisation Book 2)   Kindle Edition by  ajit roy   (Author, Editor) The Prime Minister's announcement of the withdrawal of ₹1000 and ₹500 notes ranks among the most significant economic measures taken by his government. The audacious move has given birth to hopes of a decisive blow to the black economy, terrorism and counterfeit currency. It is also being lauded for its potential to convert India into a cashless economy. The backdrop to the Budget was a fairly volatile past few months with multiple issues such as (a) demonetisation; (b) ambiguities on indirect transfer taxes; (c) treaty changes to India-Mauritius Treaty etc. Union finance minister Arun Jaitley stepped into Parliament on February 1, 2017, unveiled India’s first post demonetisation Budget. Many people have questioned if this move is the biggest disruption for electronic payments in 2016. Remone...
Post a Comment
Read more

Evaluation of Performance of Primary Fisheries Cooperative Societies (MSS) of Tripura

Evaluation of Performance of Primary Fisheries Cooperative Societies (MSS) of Tripura A.D. Upadhyay, M. Sinha, 1 , A.K. Roy, J.R. Dhanze and D.K. Pandey College of Fisheries, Central Agricultural University, Lembucherra Tripura – 799 210, India 1 Directorate of Fisheries, Govt. of Tripura, Agartala, India Email:ad_up@rediffma Abstract Fishermen cooperatives are recognized as means of socio-economic development of fishers/fish  farming community, which generally belong to weaker section of the society. The state of Tripura  has made significant progress in fish production by 197 per cent from 2004-05 to 2011-12. An  attempt has been made in this paper to analyse the status of Fishermen Cooperatives in Tripura with  respect to water holdings and fish and fish seed production. It has been found that the fishermen  cooperative in Tripura like other states of the country is not encouraging because majority of them...
Post a Comment
Read more

Statistical Methods for Genomic Sequence and Microarray Analysis

Statistical Methods for Genomic Sequence and Microarray Analysis A.K. Roy1 and S.R. Martha1 1 Central Institute of Freshwater Aquaculture Kausalyaganga,Bhubaneshwar – 751 002,Odisha Multivariate analysis methods such as Correspondence Analysis and Principle Component Analysis have often been used to identify major trends of variation in synonymous codon usage among inter or intra specific genes. Genetic codes are degenerate meaning most of amino acids can be encoded by more than one codon (triplet of nucleotides); such codons are synonymous and usually differ by one nucleotide in the third position. The alternative synonymous codons are not used with similar frequency and their usage varies among different genes. Hence there is the presence of Relative Synonymous Codon Usage values. In: Applied Bioinformatics, Statistics and Economics in Fisheries Research: pp. 29-47 © 2008 (Eds. A.K. Roy & Niranjan Sarangi) New India Publishing Agency, New Delhi (India); ISBN:97881894...
Post a Comment
Read more

Fishery resources distribution with emphasis on trends of relationship between fish seed and fish production of Assam.

Fishery resources distribution with emphasis on trends of relationship between fish seed and fish production of Assam. Author(s) :   Roy, A. K.  ;   Upadhyay, A. D.  ;   Taye, R. K.  ;   Anushree Das  ;   Rajita Devi Author Affiliation :  College of Fisheries, Central Agricultural University, Lembucherra 799 210, Tripura West, India. Author Email :   akroy1946@yahoo.co.in Journal article :   Environment and Ecology  2013 Vol.31 No.2B pp.859-863 ref.4 Abstract :  Pisciculture is considered as an important economic activity in the socio-economic context in the State of  Assam . A survey to assess the fishery resources reveals that Assam is one of the richest state in the country with surface water resources where bheel  fisheries  and pond and tank fisheries alone occupies about 1.40 lakh hectares area. Within the confined water bodies, bheel fisheries constitute 54% of to...
Post a Comment
Read more

IMPACT ASSESSMENT OF AN INTERVENTION 'IMPROVED PIG FARMING TECHNOLOGY' FOR LIVELIHOOD IMPROVEMENT OF RURAL POOR AT DHALAI DISTRICT, TRIPURA.

IMPACT ASSESSMENT OF AN INTERVENTION 'IMPROVED PIG FARMING TECHNOLOGY' FOR LIVELIHOOD IMPROVEMENT OF RURAL POOR AT DHALAI DISTRICT, TRIPURA. Ajit Kumar Roy Ex. National Consultant (IA), NAIP, Pusa, New Delhi *Corresponding author: akroy1946@yahoo.co.in Received: August 2016 Revised accepted:  September 2016 ABSTRACT Impact assessment is the process of identifying the anticipated or actual impacts of a development intervention, on social, economic and environmental factors. An impact assessment study was carried out at Ambassa,Balaram and Morachera clusters of Dhalai district, Tripura  during 2013 under NAIP project to evaluate and validate indigenous  'Improved Pig Farming Technology' (intervention) for enhancing production, profitability and competitiveness in agro ecosystem of disadvantageous areas of NEH region.Ex-post design covering both qualitative and quantitative data through random sampling and purposive selection method was taken for collection of Primary ...
1 comment
Read more

Partial Budgeting Analysis of an Intervention of ‘Land Shaping Technology’ at South 24 Parganas, West Bengal, India

Partial Budgeting Analysis of an Intervention of  ‘Land Shaping Technology’ at South 24 Parganas,  West Bengal, India Ajit Kumar Roy* Ex. Principal Scientist & Head Social Science Section,ICAR-CIFA,Kausalyaganga, Bhubaneswar, India.  Received:  November 27, 2018 ;                     Published:  December 05, 2018 Abstract  Reported Impact Assessment of an intervention ‘Land Shaping Technology’ implemented at farmer’s field under NAIP project at different villages of south 24-Pargans district of West Bengal aiming for rainwater harvesting for irrigating crops. Farm data was collected from the randomly selected farmers of both Interevent and control groups. Partial budgeting analysis was done to assess the comparative performances with respect to sources of income and livelihoods, diversification of input cost, labour cost, employment generation, production etc. The impact of Land Shaping tec...
Post a Comment
Read more

Emerging Technologies of the 21st Century

Emerging Technologies of the 21st Century June 2015; Imprint  NIPA; ISBN: 9789383305339: Year: 2015 Sections: Section 1: Biotechnology, Section  2: Nanotechnology, Section  3: Expert System Neural  Network, Section   4: Applied Technologies, Section   5: Database, Modeling, Analytics and Business Intelligence Software, Section  6: IPR & Social Issues C ontents : Preface.  Section I: Biotechnology: 1. The green revolution: clean energy and fuel  directly from algae production sy stems/Dr. Enzo Alibrandi.   2. The role of next generation  sequencing in shaping the future of life sciences research in the 21st century/Upendra Kumar  Devisetty and Lekkala Devedu Naidu. 3. Various platforms for massively parallel DNA  sequencing (Next Gene ration Sequencing)/Mamta Singh and Anindya Sundar Barman.  4. N...
Post a Comment
Read more

Development of Models for Fishery Resources and Production Statistics of West Bengal, India

Development of Models for Fishery Resources and Production Statistics of West Bengal, India Ambalika Ghosh1*, BK Mohapatra2 and AK Roy3  1Department of Fishery, Govt. of West Bengal, India  2ICAR-CIFE, GN-Bl, Salt Lake, India  3College of Fisheries, CAU, India Submission: June 8, 2017; Published: October 12, 2017 Abstract  West Bengal is rich in Inland Fishery Resources. Ponds and tanks dominate with 90.62 parent resources under culture. Overall 87.56% of total potential resource is utilized for culture leaving another 12.44% for bring under culture. Total area under of River, Canal/ Khal and Beal / Boars of West Bengal is 279569.31 ha. River occupies 58% of total area followed by canal / Khal (27%) and Beal / boar (15%). Fishermen constitute about 3.3 percent of total population of 9.13 crores in West Bengal. Fisheries are next to agriculture in terms of providing employment and food supply. Fish is an important source of quality protein and cheaper i...
Post a Comment
Read more